Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

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Introduction

  

Microfluidic Human Liver-Chip Recapitulates the In Vivo Liver Microenvironment

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Breast Cancer-Derived EVs Activate LSECs in the Liver Microenvironment

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Breast Cancer-Derived EVs Increase Breast Cancer Cell Adhesion in the Liver Microenvironment

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TGFβ1 in Breast Cancer-Derived EVs Increase Tumor Adhesion in the Liver Microenvironment

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TGFβ1-Containing EVs Increases Breast Cancer Cell Adhesion by Upregulating Fibronectin in LSECs

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EVs from the Blood of Breast Cancer Patients with Liver Metastases Contains Higher TGFβ1 Levels and Increased Adhesion of Breast Cancer Cells to the 3D Human Liver-Chip

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Conclusion

  

Reference

Kim J, Lee C, Kim I, et al. Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles[J]. ACS Nano, 2020, 14(11): 14971–14988.

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