A PDA-Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy

A PDA-Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy

  一种聚多巴胺(polydopamine,PDA)修饰的去细胞肺支架,作为研究肿瘤进展和抗癌药物筛选的功能性生物系统,并能模拟肿瘤微环境。

Introduction

  思路:

-

-

Preparation and Characterization of 3D PDA-Modified Scaffolds

  • (A)
  • (B)
  • (C)
  • (D)
  • (E)
  • (F)
  • (G)
  • (H)
  • (I)
  • (J)
  • (K)

Cell Biocompatibility, Proliferation, and Spreading on 3D PDA-Modified Scaffolds

  • (A)
  • (B)
  • (C)
  • (D)
  • (E)
  • (F)
  • (G)
  • (H)
  • (I)
  • (J)

Drug Resistance and Screening of Breast Cancer Cells on PDA-Modified Scaffolds

  • (A)
  • (B)
  • (C)
  • (D)
  • (E)
  • (F)
  • (G)
  • (H)

Mechanism of Drug Resistance Screening of Tumor Cells on 3D PDA-Modified Scaffolds

  • (A)
  • (B)
  • (C)
  • (D)
  • (E)

  • (A)
  • (B)
  • (C)
  • (D)
  • (E)

  • (A)
  • (B)
  • (C)
  • (D)
  • (E)
  • (F)
  • (G)
  • (H)
  • (I)

Immune Cells on the PDA-Modified Scaffold for Antitumor Immunotherapy

  • (A)
  • (B)
  • (C)
  • (D)
  • (E)
  • (F)
  • (G)
  • (H)
  • (I)
  • (J)
  • (K)

PDA Inhibits Reactive Oxygen Species (ROS) Level on PDA-Modified Scaffold

  • (A)
  • (B)
  • (C)
  • (D)
  • (E)

  

Discussion

-

Reference

Zhang W, Chen Y, Li M, et al. A PDA-Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy[J]. Advanced Science, 2023.

评论