一种聚多巴胺(polydopamine,PDA)修饰的去细胞肺支架,作为研究肿瘤进展和抗癌药物筛选的功能性生物系统,并能模拟肿瘤微环境。
Introduction
思路:
Preparation and Characterization of 3D PDA-Modified Scaffolds
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Cell Biocompatibility, Proliferation, and Spreading on 3D PDA-Modified Scaffolds
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Drug Resistance and Screening of Breast Cancer Cells on PDA-Modified Scaffolds
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Mechanism of Drug Resistance Screening of Tumor Cells on 3D PDA-Modified Scaffolds
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Immune Cells on the PDA-Modified Scaffold for Antitumor Immunotherapy
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PDA Inhibits Reactive Oxygen Species (ROS) Level on PDA-Modified Scaffold
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Discussion
Reference
Zhang W, Chen Y, Li M, et al. A PDA-Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy[J]. Advanced Science, 2023.